Agatolimod

Agatolimod
Identifierare
3D-modell ( JSmol )
ChemSpider
UNII
  • InChI=1S/C236H303N70O133P23S23/c1-91-47-287(223(333)269-193(91)309)157-23-105(308)130(394-157)-72-37)-72-37) 111-29-163(289-49-93(3)195(311)271-225(289)335)399-135(111)67-381-457(364.480)434-123-41-175(301) 85-247-181-187(301)257-213(241)263-207(181)323)412-148(123)80-388-443(350 466)419-108-26-150(-284(-284) 16-154(238)254-220(284)330)396-132(108)64-373-447(354,470)424-113-31-165(291-51-95(5)197(313)27 227(291)337)407-143(113)75-383-461(368,484)438-127-45-179(305-89-251-185-191(305)261-217(225)167 185)327)415-151(127)83-391-455(362,478)432-121-39-173(299-59-103(13)205(321)281-235(299)345)404-404 121)72-379-451(358,474)428-117-35-169(295-55-99(9)201(317)277-231(295)341)400-136(117)68-376-450 357.473)427-116-34-168(294-54-98(8)200(316)276-230(294)340)403-139(116)71-378-454(361.477)431-2 172(298-58-102(12)204(320)280-234(298)344)410-146(120)78-386-460(367.483)437-126-44-178(3004-88-250) 184-190(304)260-216(244)266-210(184)326)414-150(126)82-390-445(352.468)421-110-28-161(286-256-18(286-256-18) 240)256-222(286)332)398-134(110)66-374-448(355,471)425-114-32-166(292-52-96(6)198(314)274-228(292) 338)408-144(114)76-384-462(369,485)439-128-46-180(306-90-252-186-192(306)262-218(246)268-212(186) 416-152(128)84-392-456(363,479)433-122-40-174(300-60-104(14)206(322)282-236(300)346)405-141(122) 380-452(359,475)429-118-36-170(296-56-100(10)202(318)278-232(296)342)401-137(118)69-375-449-346,346, 115-33-167(293-53-97(7)199(315)275-229(293)339)402-138(115)70-377-453(360 476)430-119-37-171(297) 57-101(11)203(319)279-233(297)343)409-145(119)77-385-459(366,482)436-125-43-177(303-87-249-183-18(366 482) 303)259-215(243)265-209(183)325)413-149(125)81-389-444(351,467)420-109-27-160(285-21-17-155(239) 221(285)331)397-133(109)65-372-446(353,469)423-112-30-164(290-50-94(4)196(312)272-226(290)336)406 142(112)74-382-458(365,481)435-124-42-176(302-86-248-182-188(302)258-214(242)264-208(182)324)711 124)79-387-442(349,465)418-107-25-158(283-19-15-153(237)253-219(283)329)395-131(107)63-371-44643) 417-106-24-162(393-129(106)61-307)288-48-92(2)194(310)270-224(288)334/h15-22,47-60,85-90,105- 152,157-180,307-308H,23-46,61-84H2,1-14H3,(H,347,463)(H,348,464)(H,349,465)(H,350,466)(H,351,862)(H,351,862) 353,469)(H,354,470)(H,355,471)(H,356,472)(H,357,473)(H,358,474)(H,359,475)(H,360,476)(H,361,472)(H,361,472)(H,361,472) ,363,479)(H,364,480)(H,365,481)(H,366,482)(H,367,483)(H,368,484)(H,369,485)(H2,237,253,329)(H2,32,32,38,52,32,3,52,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,3) 1)(H2 ,240,256,332)(H,269,309,333)(H,270,310,334)(H,271,311,335)(H,272,312,336)(H,273,313,337)(H,2734,381)(H,2734,351,(H,4374,335) 276,316,340)(H,277,317,341)(H ,278,318,342)(H,279,319,343)(H,280,320,344)(H,281,321,345)(H,282,322,346)(H3,241,257,263,324)263,324)232,32,4,32,2,4,3,2,4,3,2,4,3,2,4,3,2,3,2,4,3,2,3,2,4,3,2,4,3,2,4,3,2,4,4,4,3,2,4,4,4,3,4,3,2,4 259,265,325)(H3,244,260,266,326)(H3,245,261,267,327)(H3) ,246,262,268,328)/t105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,12 -,121-,122-,123-,124-,125-,126-,127-,128-,129+,130+,131+,132+,133+,134+,135+,136+, 137+,138+,139+,140+,141+,142+,143+,144+,145+,146+,147+,148+,149+,150+,151+,152+,157+ ,158+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,171+,172+,173+,174 +,175+,176+,177+,178+,179+,180+,440?,441?,442?,443?,444?,445?,446?,447?,448?,449?, 450?,451?,452?,453?,454?,455?,456?,457?,458?,459?,460?,461?,462?/m0/s1
    Nyckel: KQQWAOVVQRSHRC-CPSXWDTOSA-N
  • InChI=1/C236H303N70O133P23S23/c1-91-47-287(223(333)269-193(91)309)157-23-105(308)130(394-157)642-40344,-374,-374-642-374 111-29-163(289-49-93(3)195(311)271-225(289)335)399-135(111)67-381-457(364.480)434-123-41-175(301) 85-247-181-187(301)257-213(241)263-207(181)323)412-148(123)80-388-443(350 466)419-108-26-150(-284(-284) 16-154(238)254-220(284)330)396-132(108)64-373-447(354,470)424-113-31-165(291-51-95(5)197(313)27 227(291)337)407-143(113)75-383-461(368,484)438-127-45-179(305-89-251-185-191(305)261-217(225)167 185)327)415-151(127)83-391-455(362,478)432-121-39-173(299-59-103(13)205(321)281-235(299)345)404-404 121)72-379-451(358,474)428-117-35-169(295-55-99(9)201(317)277-231(295)341)400-136(117)68-376-450 357.473)427-116-34-168(294-54-98(8)200(316)276-230(294)340)403-139(116)71-378-454(361.477)431-2 172(298-58-102(12)204(320)280-234(298)344)410-146(120)78-386-460(367.483)437-126-44-178(3004-88-250) 184-190(304)260-216(244)266-210(184)326)414-150(126)82-390-445(352.468)421-110-28-161(286-256-18(286-256-18) 240)256-222(286)332)398-134(110)66-374-448(355,471)425-114-32-166(292-52-96(6)198(314)274-228(292) 338)408-144(114)76-384-462(369,485)439-128-46-180(306-90-252-186-192(306)262-218(246)268-212(186) 416-152(128)84-392-456(363,479)433-122-40-174(300-60-104(14)206(322)282-236(300)346)405-141(122) 380-452(359,475)429-118-36-170(296-56-100(10)202(318)278-232(296)342)401-137(118)69-375-449-346,346, 115-33-167(293-53-97(7)199(315)275-229(293)339)402-138(115)70-377-453(360 476)430-119-37-171(297) 57-101(11)203(319)279-233(297)343)409-145(119)77-385-459(366,482)436-125-43-177(303-87-249-183-18(366 482) 303)259-215(243)265-209(183)325)413-149(125)81-389-444(351,467)420-109-27-160(285-21-17-155(239) 221(285)331)397-133(109)65-372-446(353,469)423-112-30-164(290-50-94(4)196(312)272-226(290)336)406 142(112)74-382-458(365,481)435-124-42-176(302-86-248-182-188(302)258-214(242)264-208(182)324)711 124)79-387-442(349,465)418-107-25-158(283-19-15-153(237)253-219(283)329)395-131(107)63-371-44643) 417-106-24-162(393-129(106)61-307)288-48-92(2)194(310)270-224(288)334/h15-22,47-60,85-90,105- 152,157-180,307-308H,23-46,61-84H2,1-14H3,(H,347,463)(H,348,464)(H,349,465)(H,350,466)(H,351,862)(H,351,862) 353,469)(H,354,470)(H,355,471)(H,356,472)(H,357,473)(H,358,474)(H,359,475)(H,360,476)(H,361,472)(H,361,472)(H,361,472) ,363,479)(H,364,480)(H,365,481)(H,366,482)(H,367,483)(H,368,484)(H,369,485)(H2,237,253,329)(H2,32,32,38,52,32,3,52,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,32,3) 1)(H2 ,240,256,332)(H,269,309,333)(H,270,310,334)(H,271,311,335)(H,272,312,336)(H,273,313,337)(H,2734,381)(H,2734,351,(H,4374,335) 276,316,340)(H,277,317,341)(H ,278,318,342)(H,279,319,343)(H,280,320,344)(H,281,321,345)(H,282,322,346)(H3,241,257,263,324)263,324)232,32,4,32,2,4,3,2,4,3,2,4,3,2,4,3,2,3,2,4,3,2,3,2,4,3,2,4,3,2,4,3,2,4,4,4,3,2,4,4,4,3,4,3,2,4 259,265,325)(H3,244,260,266,326)(H3,245,261,267,327)(H3) ,246,262,268,328)/t105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,12 -,121-,122-,123-,124-,125-,126-,127-,128-,129+,130+,131+,132+,133+,134+,135+,136+, 137+,138+,139+,140+,141+,142+,143+,144+,145+,146+,147+,148+,149+,150+,151+,152+,157+ ,158+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,171+,172+,173+,174 +,175+,176+,177+,178+,179+,180+,440?,441?,442?,443?,444?,445?,446?,447?,448?,449?, 450?,451?,452?,453?,454?,455?,456?,457?,458?,459?,460?,461?,462?/m0/s1
    Nyckel: KQQWAOVVQRSHRC-CPSXWDTOBP
  • Cc1cn(c(=O)[nH]c1=O)[C@H]2C[C@@H]([C@H](O2)COP(=S)(O)O[C@H]3C [C@H](O[C@H]3COP(=S)(O)O[C@H]4C[C@@H](O[C@@H]4COP(=S)(O )O[C@H]5C[C@H](O[C@H]5COP(=S)(O)O[C@H]6C[C@@H](O[C@@H] ]6COP(=S)(O)O[C@H]7C[C@H](O[C@@H]7COP(=S)(O)O[C@H]8C[C@@H] ](O[C@@H]8COP(=S)(O)O[C@H]9C[C@@H](O[C@@H]9COP(=S)(O)O[C@ H]1C[C@H](O[C@H]1COP(=S)(O)O[C@H]1C[C@@H](O[C@H]1COP(=S )(O)O[C@H]1C[C@H](O[C@@H]1COP(=S)(O)O[C@H]1C[C@@H](O[C) @@H]1COP(=S)(O)O[C@H]1C[C@@H](O[C@@H]1COP(=S)(O)O[C@H]1C[C @@H](O[C@@H]1COP(=S)(O)O[C@H]1C[C@@H](O[C@@H]1COP(=S)(O)O [C@H]1C[C@H](O[C@H]1COP(=S)(O)O[C@H]1C[C@@H](O[C@@H]1COP (=S)(O)O[C@H]1C[C@H](O[C@@H]1COP(=S)(O)O[C@H]1C[C@@H]( O[C@@H]1COP(=S)(O)O[C@H]1C[C@@H](O[C@@H]1COP(=S)(O)O[C@H] 1C[C@H](O[C@H]1COP(=S)(O)O[C@H]1C[C@@H](O[C@@H]1COP(=S)( O)O[C@H]1C[C@H](O[C@H]1COP(=S)(O)O[C@H]1C[C@@H](O[C@@ H]1CO)n1cc(c(=O)[nH]c1=O)C)n1ccc(nc1=O)N)n1cnc2c1nc([nH]c2=O)N)n1cc(c(=O)[nH]c1 =O)C)n1ccc(nc1=O)N)n1cnc2c1nc([nH]c2=O)N)n1cc(c(=O)[nH]c1=O)C)n1cc(c(=O)[nH] c1=O)C)n1cc(c(=O)[nH]c1=O)C)n1cc(c(=O)[nH]c1=O)C)n1cnc2c1nc([nH]c2=O)N)n1cc (c(=O)[nH]c1=O)C)n1ccc(nc1=O)N)n1cnc2c1nc([nH]c2=O)N)n1cc(c(=O)[nH]c1=O)C) n1cc(c(=O)[nH]c1=O)C)n1cc(c(=O)[nH]c1=O)C)n1cc(c(=O)[nH]c1=O)C)n1cnc2c1nc( [nH]c2=O)N)n1cc(c(=O)[nH]c1=O)C)n1ccc(nc1=O)N)n1cnc2c1nc([nH]c2=O)N)n1cc(c(=O )[nH]cl=O)C)O
Egenskaper
C 236 H 303 N 70 O 133 P 23 S 23
Molar massa 7698.212
Om inte annat anges ges data för material i standardtillstånd (vid 25 °C [77 °F], 100 kPa).

Agatolimod (även känd som CpG 7909, ODN 2006, PF-3512676, VaxImmune och ProMuneT) är en CpG-oligodeoxinukleotid som fungerar som en tollliknande receptor 9- agonist . Agatolimod stimulerar immunförsvaret och har testats för förebyggande och behandling av cancer, infektionssjukdomar, allergier och astma.

Sekvens

Agatolimod består av 24 deoxiribonukleotider i följande sekvens:

(TCGTCGTTTTGTCGTTTTGTC-GTT)

Hämtad från " https://en.wikipedia.org/w/index.php?title=Agatolimod&oldid=979755275 "